99.50% White Powder Aicar CAS: 2627-69-2 Treating **** Diseases|
Quick Detail of Aicar
Product name: Acadesine
Aicar Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
Aicar CAS: 2627-69-2
Aicar EINECS: 220-097-5
Aicar Molecular Formula: C9H14N4O5
Aicar Molecular Weight: 258.23
Aicar Assay: 98%
Aicar Apperance: White or off-white powder.
Aicar Usage: Pharmaceutical intermediates. For the treatment of **** diseases
Functions of Aicar
AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
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