Fildena, a brand of sildenafil citrate, is primarily used to treat ED by increasing blood flow to the pill. It works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5). When combined with antifungal drugs, the interaction largely depends on the specific antifungal agent used, as they can affect the metabolism of sildenafil.
Many antifungal drugs, particularly those in the azole class (e.g., ketoconazole, itraconazole, fluconazole), are known to inhibit cytochrome P450 enzymes, especially CYP3A4, which play a key role in metabolizing sildenafil. When these antifungals are taken alongside sildenafil, they can increase sildenafil's concentration in the bloodstream, potentially leading to an enhanced or prolonged effect, which may increase the risk of side effects like headache, dizziness, flushing, or even more serious issues.
Therefore, it's important for individuals on antifungal therapy to exercise caution when using sildenafil, and vice versa. Dose adjustments may be necessary to mitigate risks. Always consult a healthcare provider for guidance when combining these medications to ensure safety and effectiveness.http://www.genericday.com/fildena.html »
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